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Nucletron B V
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SAS institute
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Vista LifeSciences
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STATSports Technologies Ltd
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BIOPAC
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Med Man Simulations Inc
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Continuum Analytics Inc
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Curexo Technology Corporation
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ALARIS Inc
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SAS institute
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Image Search Results
Journal: Children
Article Title: Effect of a Larger Flush Volume on Bioavailability and Efficacy of Umbilical Venous Epinephrine during Neonatal Resuscitation in Ovine Asphyxial Arrest
doi: 10.3390/children8060464
Figure Lengend Snippet: Schematic showing the speculative mechanism of larger flush volume following low umbilical venous catheter (UVC) epinephrine in term newborns. During cardiac arrest (absence of spontaneous cardiac activity) and during chest compressions and positive pressure ventilation (PPV) that increase the intrathoracic pressure and cause back pressure in the inferior vena cava, the epinephrine injected via a low umbilical venous catheter followed by a low flush volume of 0.5 mL to 1 mL may not be delivered to the right atrium. The epinephrine may be deposited in the umbilical vein or hepatic veins. The use of a higher flush volume may propel the epinephrine to the right atrium and across the patent foramen ovale (PFO) to left heart, aorta, systemic circulation, and coronary arteries increasing the chances of return of spontaneous circulation (ROSC). Inset shows a magnified view of the heart and coronary vessels. The yellow line represents the path of epinephrine and flush in the figure and the inset. Copyright Satyan Lakshminrusimha.
Article Snippet: Hemodynamic variables were continuously monitored during asphyxia, resuscitation and after
Techniques: Activity Assay, Injection